Medical Definition of Alpha-synucleinbrain lesions that are hallmarks of some neurodegenerative diseases (synucleinopathies). The gene for alpha-synuclein, which is called SNCA, is on chromosome 4q21. Defects in this protein are believed to be related to the development of Parkinson disease.See also: Parkinson disease gene.
Last Editorial Review: 6/9/2016
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