The Women's Health Initiative in Perspective: The Last Straw for Estrogen Therapy?

Medical Author: Carolyn Crandall, MD.,FACP
Medical Editor: William C. Shiel, Jr., MD, FACP, FACR

If we piled up all the medical research that's been done in the last 30 years about estrogen therapy in menopausal women, we could probably fill up a mega-warehouse. The strange thing is that such a small portion of the research was done in a way that was scientifically rigorous and demanding, and not a single reliable study told us the overall benefits that healthy women could expect after using estrogen therapy for several years...until now.

The Women's Health Initiative (WHI) was the first randomized controlled trial of estrogen/progestin therapy (EPT) designed to determine the long-term balance of benefit versus risk in healthy menopausal women. It was the first randomized trial assessing whether EPT has a benefit on coronary heart disease incidence in healthy women. The results were reported in a series of articles in JAMA in 2002 and 2003.

Why should we hold out for large randomized controlled trials? A randomized trial assigns each woman to either EPT or placebo (sugar pill) without her knowing and without the researchers knowing, which therapy she is taking. Unfortunately, we learned from the past that women who take estrogen tend to be healthier in general than women who do not choose to take estrogen. Frequently the reason women who chose to be on estrogen had fewer heart attacks, or less dementia was because they were healthier for other reasons. Women who take estrogen often have healthier diets, more money, more education, lower body weight, and exercise more - things that on their own predict fewer heart attacks or dementia. Therefore, we need to have research in which the women who were taking the EPT were as similar as possible in these health characteristics to the women in the study taking the placebo. Studies in which women can choose to take or not take estrogen are not going to give us the answers we need. Before the WHI, many people thought estrogen would be protective against heart disease, dementia, and stroke, on the basis of studies that were not randomized. Fortunately, the WHI came along to give definite answers. The answers surprised many people.

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