Does Garlic Prevent Cancer?
Garlic is the edible bulb from a plant in the lily family. Garlic, onions, leeks, scallions, shallots, and chives are classified as members of the Allium genus. Thus, they are commonly described as Allium vegetables.
Does garlic prevent cancer?
Can "too much" garlic be harmful?
Although health benefits of garlic are frequently reported, excessive intake can have harmful effects. Studies have reported symptoms including garlic odor on breath and skin, occasional allergic reactions, stomach disorders and diarrhea, decrease in serum protein and calcium levels, association with bronchial asthma and contact dermatitis, and possible associations with production of sperm in males. Garlic preparations vary in concentration and in the number of active compounds they contain. Thus, quality control is an important consideration when foods such as garlic are considered for use as a cancer-fighting agent.
How might garlic prevent cancer?
The chemistry of garlic is complicated. As a result, the quality of garlic products depends on the manufacturing process. Peeling garlic and processing garlic into oil or powder can increase the number and variety of active compounds. Peeling garlic releases an enzyme called allinase and starts a series of chemical reactions that produce diallyl disulfide (DADS). DADS is also formed when raw garlic is cut or crushed. However, if garlic is cooked immediately after peeling, the allinase is inactivated and the cancer-fighting benefit of DADS is lost. Some scientists recommend waiting 15 minutes between peeling and cooking garlic to allow the allinase reaction to occur.
Processing garlic into powder or garlic oil releases other cancer-fighting
agents. The inconsistent results of garlic research may be due, at least in
part, to problems standardizing all of the active compounds within garlic
preparations. Some of the garlic compounds currently under investigation are:
allin (responsible for the typical garlic odor), alline (odorless compound),
ajoene (naturally occurring disulfide), diallyl sulfide (DAS), diallyl disulfide
(DADS), diallyl trisulfide (DAT), S-allylcysteine (SAC), organosulfur compounds,
and allyl sulfur compounds.
Portions of the above information has been provided with the kind permission of the National Cancer Institute, National Institutes of Health (www.nci.nih.gov/).
Last Editorial Review: 6/9/2003
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