Osteoarthritis - 2001 National Meeting Reports (cont.)
Valdecoxib was shown to be beneficial in treating
osteoarthritis of the hip.
Etoricoxib is another Cox-2 NSAID that is being investigated for the treatment of rheumatoid arthritis and osteoarthritis (see Valdecoxib above). Previous studies have demonstrated its effectiveness in relieving the signs and symptoms of joint inflammation.
This experimental drug was shown to be effective
in the treatment of osteoarthritis of the knee and hip in over 200
Fewer patients treated with etoricoxib had to
discontinue the medication because of gastrointestinal complications as compared
with the traditional NSAIDs, Voltaren, and Naprosyn.
Complementary and alternative medicines (CAM) are
being used by 33% of osteoarthritis patients. It was also shown that these
patients seem to be more cautious about their health, seeking specialists' care
Glucosamine (a radioactive form that could be
identified in tissues) taken by mouth was found to be incorporated into the
cartilage of Beagle dogs.
September 30, 2004 the Food and Drug Administration (FDA) today acknowledged the voluntary withdrawal from the market of Vioxx (chemical name rofecoxib), a nonsteroidal antiinflammatory drug (NSAID) manufactured by Merck & Co. FDA today also issued a Public Health Advisory to inform patients of this action and to advise them to consult with a physician about alternative medications.
Merck withdrew Vioxx from the market after the data safety monitoring board overseeing a long-term study of the drug recommended that the study be halted because of an increased risk of serious cardiovascular events, including heart attacks and strokes, among study patients taking Vioxx compared to patients receiving placebo. The study was being done in patients at risk of developing recurrent colon polyps.