From Our 2013 Archives
Nexavar Approval Expanded for Common Thyroid Cancer
Latest Cancer News
FRIDAY, Nov. 22, 2013 (HealthDay News) -- U.S. Food and Drug Administration approval for the anti-cancer drug Nexavar (sorafenib) has been expanded to include late-stage differentiated thyroid cancer, the most common type of thyroid cancer.
Nexavar is designed to inhibit proteins that prompt cancer cells to divide and grow. The new approval is meant for people with differentiated thyroid cancer that no longer responds to radioactive iodine treatment.
The drug was approved for this new use based on clinical studies involving 417 people whose thyroid cancer did not respond to treatment. The drug increased the time recipients lived without cancer progression by about 41 percent compared to those who took a placebo, the FDA said.
The most common side effects of Nexavar included diarrhea, fatigue, infection, hair loss, skin reactions, weight loss, loss of appetite, abdominal pain and high blood pressure. The agency also warned that increased production of thyroid stimulating hormone -- a potential promoter of thyroid cancer -- was possible among the drug's users.
The drug is marketed by Bayer HealthCare Pharmaceuticals, based in Wayne, N.J.
-- Scott Roberts