From Our 2013 Archives
Obesity, Exercise May Affect Risk for Key Type of Colon Cancer
Latest Cancer News
Researchers analyzed data from women in the U.S. Nurses' Health Study and men in the Health Professionals Study to determine if there was a link between weight, exercise and the risk for CTNNB1-positive or CTNNB1-negative colorectal cancer.
CTNNB1 is a molecule implicated in cancer and obesity.
A higher body-mass index, or BMI (a measurement of body fat based on height and weight), was associated with an increased risk of CTNNB1-negative colorectal cancer, while physical activity was associated with a lower risk.
BMI and physical activity had no effect on the risk for CTNNB1-positive colorectal cancer, according to the study appearing Feb. 26 in the journal Cancer Research.
"Our results provide additional evidence for a causal role of obesity and a physically inactive lifestyle in a specific molecular subtype of colorectal cancer," Dr. Shuji Ogino, an associate professor of pathology at Dana-Farber Cancer Institute and an associate professor in the department of epidemiology at Harvard School of Public Health, said in a journal news release.
"If physicians are able to identify individuals who are prone to develop CTNNB1-negative cancer, then it would be possible to strongly recommend physical activity," Ogino added.
The findings also suggest that CTNNB1 could be a potential target for drugs to prevent and treat colorectal cancer in certain patients, Ogino said.
-- Robert Preidt
SOURCE: Cancer Research, news release, Feb. 26, 2013