I recently had
an ANA test and the results were 1:640 homogenous. Symptoms of tingling
face, arms, extreme fatigue and muscle weakness. Should I contact a
rheumatologist? Also, had double stranded DNA 2 years ago, it was
negative. Could this change and does that test confirm SLE?
Antinuclear antibodies (ANA), are used by doctors as screening tests to detect the possible presence of an autoimmune condition. They may or may not necessarily be associated with such a condition. If your doctor is satisfied that your ANA has helped his/her adequately to evaluate your particular health status, then no other evaluations that may be required.
Rheumatologists are experts at searching for conditions that can be associated with ANAs.
Double-stranded DNA (ds - DNA) test values fluctuate and may become negative over time.
System Lupus Erythematosus is diagnosed primary based on the presence of multiple standard criteria - only one of which is the ds-DNA.
Thank you for your question.
Last Editorial Review: 2/3/2003