Definition of Southern blot
In the Southern blot technique, DNA fragments are separated by a method called agarose gel electrophoresis, transferred (blotted) onto membrane filters, and hybridized with complementary radiolabeled probes. The aim is to detect specific base sequences with the probes.
Lest all of this sound esoteric, note that in the television series "The X Files" a Southern blot was done (in this case, to learn if some alien virus genome had been integrated into a person's genome).
Last Editorial Review: 6/14/2012
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