Plavix Treatment Associated with TTP

Thrombotic thrombocytopenic purpura (TTP) is a serious, potentially fatal condition in which blood clots form in the arteries. The clots block the flow of blood to the organs, especially the brain and kidneys, and damage them. In addition, destruction of red blood cells and platelets within the arteries causes anemia and bleeding. TTP is a very rare condition, occurring in only four out of every million individuals; however, it may occur with increased frequency with pregnancy, AIDS, cancer, vaccinations and treatment with drugs such as cyclosporine (Sandimmune), oral contraceptives, ticlopidine (Ticlid) and some drugs used for treating cancer. A new association of TTP and the drug Plavix (clopidogrel) will be reported in the New England Journal of Medicine, but because of the potential importance to patients of this association, the Journal has posted the study's results on its web site prior to publication.