Definition of Currarino syndrome
Currarino syndrome: Failure of formation of all or part of the sacrum (the lowest section of the spine).
Currarino syndrome is a condition characterized by the combination of:
The malformations in Currarino syndrome are all in tissues that have their embryological origin in the tail bud and may reflect disturbances in its formation during early embryonic life. A mutation (change) in a gene called the HLXB9 homeobox gene has been identified as responsible for autosomal dominant Currarino syndrome, also known as hereditary sacral agenesis.
Last Editorial Review: 6/14/2012
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