Study: Calcium May Increase Heart Attack Risk
But Experts Say Evidence Is Not Convincing
By Salynn Boyles
WebMD Health News
Reviewed by Laura J. Martin, MD
July 29, 2010 -- Millions of people who take calcium supplements in hopes of
lowering their risk for bone fractures may actually be increasing their risk of
having a heart attack, new research suggests.
An analysis of close to a dozen clinical trials involving about 12,000
patients found calcium supplementation to be associated with a 20% to 30%
increase in heart attack risk.
Researcher Ian Reid, MD, of New Zealand's University of Aukland says it is
time to reassess the role of calcium supplementation for the treatment and
prevention of osteoporosis.
"I think we need to seriously consider whether calcium supplementation is a
good thing for most people, given that it is associated with a very small
decrease in fracture risk," he tells WebMD.
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Calcium, Heart Attack Findings
Just over two years ago, Reid's own research unexpectedly showed a slight
increase in heart attacks among healthy, older women who took calcium
supplements to prevent fractures.
"Our hypothesis when we started the study was that calcium would protect the
heart," he says.
In an effort to confirm the earlier findings, Reid and colleagues from the
University of Aberdeen in the U.K. and Dartmouth University in the U.S. combined
and analyzed the findings from 11 randomized trials in which participants took
calcium supplements (500 milligrams or more per day) without vitamin D.
After adjusting for differences in study design, the researchers concluded
that calcium supplementation was associated with a modest increase in risk for
heart attacks, but not for strokes or death from
heart disease.
Reid speculates that calcium supplements may rapidly elevate blood calcium
levels, which could contribute to artery disease.
Calcium from food sources is absorbed much more slowly, he says.
The study appears today in the journal BMJ Online First.
"We encourage our patients to get their calcium from the foods they eat and
not from supplements," he says.
Calcium-Bone Link 'Weak'
In an interview with WebMD, cardiologist John Cleland of the U.K.'s Hull York
Medical School called the analysis "concerning but not convincing" in linking
calcium supplementation to heart attacks.
"Heart attacks are serious business, so you would expect to see an increase
in mortality in supplement users along with heart attacks," he says. "The fact
that this wasn't seen makes me wonder if this intervention is changing the
perception rather than the reality of this outcome."
But Cleland says the evidence that calcium or calcium with vitamin D protects
against bone fracture is also far from convincing.
In an editorial published with the study, Cleland and colleagues write that
calcium supplements alone do not prevent fractures and may even slightly
increase fracture risk.
"Given the uncertain benefits of calcium supplements, any level of (heart)
risk is unwarranted," they conclude.
Cleland says people with osteoporosis should be taking medications, not
supplements, to treat the disease.
Cardiologist Nieca Goldberg, MD, who directs the NYU Women's Heart Program,
recommends calcium supplements only to patients who don't get much calcium in
their diets.
"If they are eating a lot of low-fat dairy products or other foods with
calcium, they may not need much supplementation," she says. "People don't always
realize how much calcium they are getting in their diets."
Goldberg, who is a spokeswoman for the American Heart Association, echoes
Cleland's concerns about the newly published analysis.
"It is hard to understand how calcium could increase the risk for heart
attack and not for stroke or death if this association is real," she says.
SOURCES:
Bolland, M.J. BMJ Online First, July 30, 2010.
IIan R. Reid, MD, professor of medicine and endocrinology, University of
Aukland, New Zealand.
John G.F. Cleland, MD, professor of medicine, Hull York Medical School,
University of Hull, Kingston upon Hull, U.K.
Nieca Goldberg, MD, medical director, New York University Women's Heart Program;
spokeswoman, American Heart Association.
News release, BMJ Online First, July 30, 2010.
WebMD Health News: "Calcium: Heart Risk for Older Women?"
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