From Our 2010 Archives
Gene Holds Key to Embryonic Stem Cell Rejuvenation
WEDNESDAY, March 24 (HealthDay News) -- Scientists have identified a gene in mice that is a key player in what could essentially be called embryonic stem cells' "immortality."
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Embryonic stem cells can develop into nearly any type of cell in the body and can produce infinite generations of new, fully operational embryonic stem cells (daughter cells). But the mechanism for this rejuvenation has been a mystery, the researchers noted in a news release from the U.S. National Institute on Aging (NIA).
In the new study, researchers at the NIA found that embryonic stem cells in mice express a unique Zscan4 gene that enables them to continuously produce vigorous daughter cells.
According to the study authors, this gene isn't turned on every time an embryonic stem cell replicates; only about 5% of embryonic stem cells will have the gene activated at any one point.
-- Robert Preidt
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SOURCE: U.S. National Institute on Aging, news release, March 24, 2010