Medical Definition of XenograftXenograft: A surgical graft of tissue from one species to an unlike species (or genus or family). A graft from a baboon to a human is a xenograft. The prefix "xeno-" means foreign. It comes from the Greek word "xenos" meaning stranger, guest, or host. (Xeno- and xen- are variant forms of the same prefix.) Last Editorial Review: 5/13/2016
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