Cymbalta for Fibromyalgia Treatment (cont.)
Other side effects that may occur include:
You may feel dizzy upon standing when you first start taking Cymbalta or when your dose is increased. This is due to a drop in blood pressure, and is known as orthostatic hypotension. Your health care provider may want to check your blood pressure from time to time while you are taking Cymbalta.
Risks and Warnings
Cymbalta and other antidepressants may increase the risk for suicidal thoughts and behaviors in people under age 24. After you are prescribed Cymbalta, your doctor will monitor you closely for unusual behavior changes, new or worsening signs of depression, or suicidal thoughts.
Cymbalta may cause a drop in salt (sodium) levels in the blood, a potentially life-threatening condition called hyponatremia. Older adults, particularly those who take diuretics ("water pills") are more likely to develop this complication. Hyponatremia can cause headaches, confusion, weakness, and in severe cases can lead to fainting, seizures, coma, and death.
Some patients taking Cymbalta have developed liver problems. In rare cases, this has lead to liver failure and death. Contact your health care provider immediately if you develop any of the following symptoms while taking Cymbalta:
In rare cases, a life-threatening condition called serotonin syndrome has occurred in patients who have taken Cymbalta. Serotonin syndrome most often results when someone takes two or more medications that increase the body's serotonin levels at the same time. You need serotonin for your brain and nerve cells to function, but too much of it can be dangerous. Serotonin syndrome can lead to rapid changes in blood pressure, muscle rigidity, seizures, and even death.
This is why it is so important that your health care providers know what medications you are taking. Always tell them about all the medicines you take, including over-the-counter drugs and herbs and supplements.
Drugs that may interact with Cymbalta and cause serotonin syndrome include:
Other drugs may also interact with Cymbalta, including:
Before You Take Cymbalta
Tell your doctor about any other medical conditions you may have. The drug should be prescribed with caution in those who have:
Who Should Not Take Cymbalta?
You should not take Cymbalta if you:
In animal studies Cymbalta has demonstrated adverse effects on a developing fetus. No adequate or well-controlled studies of the drug have been performed in pregnant or breastfeeding women. Women who are breastfeeding, pregnant, or planning to become pregnant should talk to their doctor about whether or not Cymbalta is right for them. You should only take Cymbalta if the benefits outweigh the risks.
WebMD Medical Reference
Last Editorial Review: 8/7/2009
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