saquinavir, Invirase (Fortovase - discontinued) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

When digoxin is taken by patients receiving saquinavir (Invirase) with ritonavir (Norvir), the amount of digoxin (Lanoxin) in the body can increase by 50%, possibly leading to side effects such as potentially fatal rhythm disturbances, nausea, vomiting, and diarrhea, blurred or yellow vision; headache; weakness; dizziness; apathy; confusion; and mental disturbances such as anxiety, depression, delirium, and hallucinations.

PREGNANCY: Use of saquinavir during pregnancy has not been adequately evaluated.

NURSING MOTHERS: It is not known whether saquinavir is secreted in breast milk. Nevertheless, HIV-infected mothers should not breast-feed because of the potential risk of transmitting HIV to an infant that is not infected.

SIDE EFFECTS: The most frequent side effects are headache, weakness, diarrhea, nausea and stomach discomfort. Saquinavir also may cause skin reactions, liver failure, seizures and failure of the pancreas (pancreatitis). Like other protease inhibitors, use of saquinavir may be associated with redistribution or accumulation of body fat, increased cholesterol and worsening of diabetes.

Reference: FDA Prescribing Information

Last Editorial Review: 8/12/2011

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