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SAQUINAVIR-ORAL SOFTGEL CAPSULES, Fortovase (cont.)

SIDE EFFECTS: Nausea, stomach upset, muscle or joint pain, cough or diarrhea may occur. If these symptoms continue or become severe, inform your doctor. Notify your doctor if you experience: confusion, loss of coordination, severe weakness, depression, skin rash, unusual bruising or bleeding, stomach pain, hearing or vision difficulty, fever, chills, increased urination, thirst, unusual fatigue, persistent sore throat, yellowing of the eyes or skin. Changes in body fat may occur while you are taking this medication (e.g., increased fat in the upper back and stomach areas, decreased fat in the arms and legs). The cause and long-term effects of these changes are unknown. Discuss the risks and benefits of therapy with your doctor, as well as the possible role of exercise to reduce this side effect. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Before taking this, tell your doctor if you have: liver disease, diabetes, blood disorders, any allergies. This may make you more sensitive to the sun than usual. Avoid sun exposure. Use a sunscreen and wear protective clothing when outdoors. Tell your doctor if you are pregnant before using this medication. It is not known if this drug is excreted into breast milk. HIV infected mothers are advised to avoid breast-feeding in order to protect the infant from becoming infected with HIV.

DRUG INTERACTIONS: This drug should not be used with the following medications because very serious interactions may occur: terfenadine, astemizole, cisapride, triazolam, midazolam, ergot alkaloids and derivatives (e.g., ergotamine), cholesterol-lowering drugs (e.g., statins such as lovastatin, simvastatin), St. John's wort, rifamycins (e.g., rifabutin, rifampin), antiarrhythmic drugs (e.g., amiodarone, propafenone, quinidine). If you are currently using any of these medications, tell your doctor or pharmacist before starting saquinavir. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of: insulin, anti-diabetic medications, phenobarbital, phenytoin, dexamethasone, carbamazepine, calcium channel blockers (e.g., diltiazem, nifedipine), clindamycin, dapsone, nelfinavir, indinavir, ritonavir, delavirdine, nevirapine, sildenafil, clarithromycin, ketoconazole. This drug may interfere with the effectiveness of birth control pills. Discuss using other methods of birth control with your doctor. Do not start or stop any medicine without doctor or pharmacist approval.



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