SAPHO Syndrome
Medical Author: William C. Shiel Jr., MD, FACP, FACR
What is SAPHO syndrome?
SAPHO syndrome is a chronic disorder that involves the skin, bone, and joints. SAPHO is an eponym for the combination of synovitis,
acne, pustulosis, hyperostosis, and osteitis.
Synovitis means inflammation of the joint lining (synovium).
Typically, this is manifests as warmth, tenderness, pain, swelling,
and stiffness of involved joints (arthritis).
Acne is a skin condition featuring tiny areas of inflammation
with pus formation at the hair follicles. Acne occurs most commonly
on the face and upper back.
Pustulosis is a very inflammatory skin condition resulting in
large fluid-filled blister-like areas (pustules), typically on
the palms of the hands and/or the soles of the feet. The skin
of these areas peels and flakes (exfoliates).
Hyperostosis means abnormal excessive growth of bone. The
hyperostosis
of the SAPHO syndrome frequently is located at the points of the
bone where tendons attach.
Osteitis means inflammation of the bone. Patients with SAPHO
syndrome can develop inflammation of the sacroiliac joints
(sacroiliitis) as well as inflammation of the spine (spondylitis)
which leads to stiffness and pain of the neck and back.
Is SAPHO syndrome related to other joint conditions?
Some researchers feel that the SAPHO syndrome is related to the
group of arthritis conditions which typically affect the spine,
called the spondyloarthropathies. For further information, please read the
Ankylosing Spondylitis and
Reactive Arthritis articles.
What is treatment for SAPHO syndrome?
Treatment of patients with SAPHO syndrome is directed toward the
individual symptoms that are present. Generally, treatment involves
medications that reduce inflammation in the particular tissues affected. Examples of medications that are used for inflammation include nonsteroidal antiinflammatory drugs (NSAIDs, such as
aspirin, ibuprofen, and naproxen) and cortisone medications (either in the form of topical creams, tablets, or by injection into the involved area). Topical cold applications can also help reduce inflammation in some tissues. For patients with persisting joint symptoms, both sulfasalazine and methotrexate have been tried with varying degrees of success.
- SAPHO syndrome is a chronic disorder that involves the skin, bone, and joints.
- SAPHO is an eponym for the combination of synovitis,
acne, pustulosis, hyperostosis, and osteitis.
- Some researchers feel that the SAPHO syndrome is related to the
group of arthritis conditions which typically affect the spine,
called the spondyloarthropathies.
- Treatment of SAPHO syndrome typically involves medications which reduce inflammation.
Last Editorial Review: 11/2/2007
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