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How does SAMe work?

The body uses SAMe to make certain chemicals in the body that play a role in pain, depression, liver disease, and other conditions. People who don't make enough SAMe naturally may be helped by taking SAMe as a supplement.

Are there safety concerns?

SAMe is LIKELY SAFE for most people. It can sometimes cause gas, vomiting, diarrhea, constipation, dry mouth, headache, mild insomnia, anorexia, sweating, dizziness, and nervousness, especially at higher doses. It can make some people with depression feel anxious.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the safety of using SAMe during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Children: SAMe is POSSIBLY SAFE when usedtaken by mouth andor used intravenously (by IV) in children in the short-term.

Bipolar disorder: Use of SAMe can cause people with bipolar disorder to convert from depression to mania.

Parkinson's disease: SAMe might make Parkinson's symptoms worse.

Surgery: SAMe might affect the central nervous system. This could interfere with surgery. Stop taking SAMe at least 2 weeks before a scheduled surgery.


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