pain, depression, liver disease, and other conditions. People who don't make enough SAMe naturally may be helped by taking SAMe as a supplement.
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gas, vomiting, diarrhea, constipation, dry mouth, headache, mild insomnia, anorexia, sweating, dizziness, and nervousness, especially at higher doses. It can make some people with depression feel anxious.
Special Precautions & Warnings:Pregnancy and breast-feeding: Not enough is known about the safety of using SAMe during pregnancy and breast-feeding. Stay on the safe side and avoid use.
Children: SAMe is POSSIBLY SAFE when usedtaken by mouth andor used intravenously (by IV) in children in the short-term.
Bipolar disorder: Use of SAMe can cause people with bipolar disorder to convert from depression to mania.
Parkinson's disease: SAMe might make Parkinson's symptoms worse.
Surgery: SAMe might affect the central nervous system. This could interfere with surgery. Stop taking SAMe at least 2 weeks before a scheduled surgery.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.