samarium sm-153/lexidronam - injection, Quadramet
GENERIC NAME: SAMARIUM SM-153/LEXIDRONAM - INJECTION (sa-MARE-ee-um SM 153/lexi-DROH-nam)
BRAND NAME(S): Quadramet
Medication Uses | How To Use | Side Effects |
Precautions | Drug Interactions | Overdose | Notes |
Missed Dose | Storage
USES: This product contains a radioactive medication. It is used to treat pain caused by cancer that has spread to the bone. It may help to make you more comfortable and may allow you to decrease the amount of pain medications you take.
HOW TO USE: This medication is injected into a vein as directed by your doctor. The dosage is based on your weight. Because this medication is radioactive, it is given only by specially trained health care professionals who must follow all proper use and handling instructions.Radioactive drug will be present in your urine for several hours after you receive the dose. Too much radiation can damage the bladder, so it is important to make sure the medication passes out of the bladder as soon as possible. Therefore, drink at least 2 glasses (16 ounces or 500 milliliters) of water or other fluid before receiving this medication, and urinate as often as possible after receiving the dose. Your doctor may decide to give these fluids by vein. Consult your doctor for details.Also, to make sure you and those around you are exposed to as little radiation as possible, take the following precautions for at least 12 hours after the dose. Use a toilet instead of a urinal, and flush the toilet several times after each use. Clean up any blood and spilled urine immediately. Wash your hands thoroughly after urinating or coming in contact with blood. If blood or urine gets onto clothing, wash the clothing separately from other clothes, or store them safely in a separate place for 1 to 2 weeks to give the radiation time to become less harmful. Consult your doctor or pharmacist for more information.You may have mild, temporary worsening of pain within the first 3 days after receiving the dose. You may start to feel pain relief 1 week after the dose. The best pain relief generally occurs after 3 to 4 weeks. Consult your doctor or pharmacist about the use of other pain medications for sudden attacks of pain.
SIDE EFFECTS: Diarrhea, dizziness, or a temporary increase in bone pain (pain flare) may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Many people using this medication have serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk.This medication can lower the body's ability to fight an infection. Tell your doctor promptly if you develop any signs of an infection (e.g., fever, chills, persistent sore throat/cough, pain when you urinate).Tell your doctor immediately if any of these unlikely but serious side effects occur: easy or unusual bleeding/bruising (e.g., bloody nose, bloody/black/tarry stools, bloody/pink urine), unusual weakness/tiredness, pounding/persistent headache, fast/slow/irregular heartbeat.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice any other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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