salsalate, Amigesic, Salflex, Argesic-SA, Marthritic, Salsitab, Artha-G (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 500 and 750 mg
STORAGE: Salsalate should be stored at room temperature, 15 C (59 F - 86 F).
PRESCRIBED FOR: Salsalate is used for treating rheumatoid arthritis and osteoarthritis. It also is used for the treatment of inflammation and pain resulting from soft tissue injuries, tendinitis, bursitis, and similar conditions.
DOSING: The usual dose of salsalate is 3000 mg daily given over 2-4 doses. Salsalate should be taken with food to reduce stomach upset.
DRUG INTERACTIONS: Salsalate, like aspirin, is converted to salicylic acid. Therefore, adding aspirin to salsalate can cause salicylic acid toxicity.
NSAIDs may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins play a role in the regulation (lowering) of blood pressure.
When NSAIDs are combined with methotrexate (Rheumatrex, Trexall) or aminoglycoside antibiotics (for example, gentamicin) the blood levels of methotrexate or aminoglycoside may increase, presumably because the elimination of methotrexate or aminoglycosides is reduced. This may lead to more side effects from methotrexate or aminoglycosides.
Persons who have more than 3 alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking NSAIDs.
Medically Reviewed by a Doctor on 10/30/2014
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