salsalate, Amigesic, Salflex, Argesic-SA, Marthritic, Salsitab, Artha-G

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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DOSING: The usual dose of salsalate is 3000 mg daily given over 2-4 doses. Salsalate should be taken with food to reduce stomach upset.

DRUG INTERACTIONS: Salsalate, like aspirin, is converted to salicylic acid. Therefore, adding aspirin to salsalate can cause salicylic acid toxicity.

NSAIDs may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.

NSAIDs may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins play a role in the regulation (lowering) of blood pressure.

When NSAIDs are combined with methotrexate (Rheumatrex, Trexall) or aminoglycoside antibiotics (for example, gentamicin) the blood levels of methotrexate or aminoglycoside may increase, presumably because the elimination of methotrexate or aminoglycosides is reduced. This may lead to more side effects from methotrexate or aminoglycosides.

Individuals taking oral blood thinners or anticoagulants, for example, warfarin (Coumadin), should avoid NSAIDs because NSAIDs also thin the blood, and excessive blood thinning may lead to bleeding.

Persons who have more than 3 alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking NSAIDs.

PREGNANCY: There are no adequate studies of salsalate in pregnant women.

NURSING MOTHERS: Salicylic acid appears in breast milk at levels close to maternal blood levels. This may cause adverse effects in the infant. Nursing women should avoid nursing while taking salsalate or use alternate drugs.

Medically Reviewed by a Doctor on 10/30/2014

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