DOSING: The usual dose of salsalate is 3000 mg daily given over 2-4 doses. Salsalate should be taken with food to reduce stomach upset.
DRUG INTERACTIONS: Salsalate, like aspirin, is converted to salicylic acid. Therefore, adding aspirin to salsalate can cause salicylic acid toxicity.
NSAIDs may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins play a role in the regulation (lowering) of blood pressure.
When NSAIDs are combined with methotrexate (Rheumatrex, Trexall) or aminoglycoside antibiotics (for example, gentamicin) the blood levels of methotrexate or aminoglycoside may increase, presumably because the elimination of methotrexate or aminoglycosides is reduced. This may lead to more side effects from methotrexate or aminoglycosides.
Persons who have more than 3 alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking NSAIDs.
PREGNANCY: There are no adequate studies of salsalate in pregnant women.
NURSING MOTHERS: Salicylic acid appears in breast milk at levels close to maternal blood levels. This may cause adverse effects in the infant. Nursing women should avoid nursing while taking salsalate or use alternate drugs.
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