salmeterol, Serevent (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

SIDE EFFECTS: Side effects include:

Throat and upper airway irritation can occur.

Use of long acting drugs like salmeterol may increase the risk of asthma-related death. Therefore, salmeterol should only be used in patients uncontrolled by other agents and who are using other long-term asthma-controlling medications such as an inhaled corticosteroid.

PRESCRIPTION: yes

GENERIC AVAILABLE: no

PREPARATIONS: Canisters (13g with 120 inhalations and 6.5g with 60 inhalations).

STORAGE: Salmeterol should be stored from 36 F to 86 F (2.2 C to 30 C). The canister should be kept away from heat or flame and not punctured; it should not be frozen or placed in direct sunlight .

DOSING: Salmeterol inhalations should not be used more often than prescribed (twice per day) and proper techniques of inhalation closely followed. Salmeterol is metabolized by the liver and should be used with caution in patients with liver dysfunction. Salmeterol is not meant to be used in treating acute asthma attacks; short acting inhaler medications are used for acute attacks. When using salmeterol in preventing exercised induced asthma, the medication is administered 30 to 60 minutes before exercise. Salmeterol does not take the place of oral or inhaled corticosteroids.

DRUG INTERACTIONS: Salmeterol can increase heart rate, blood pressure, and cause chest pain and excitement, especially if used in higher doses than recommended or used in those with coronary heart disease or high blood pressure. Tricyclic antidepressants and salmeterol should not be combined because of additive effect on the vascular system. In rare instances, salmeterol can induce paradoxical worsening of bronchospasm (which can be life-threatening). If this occurs, salmeterol should be discontinued, and the doctor notified immediately. Rare allergic reactions to salmeterol can cause skin rash, hives, swelling, bronchospasm, and anaphylaxis. Worsening of diabetes and lowering of potassium have also been described.

Medically Reviewed by a Doctor on 5/18/2015


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