ramelteon, Rozerem

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GENERIC NAME: ramelteon


DRUG CLASS AND MECHANISM: Ramelteon is an oral drug that promotes falling asleep and is used for treating insomnia. It acts by stimulating receptors for melatonin in the brain. Melatonin and its receptors control the circadian rhythm of the body which controls the sleep/wake cycle. Unlike many drugs used for treating insomnia, ramelteon is not addictive, and it is not a controlled substance. Ramelteon also does not cause withdrawal symptoms or rebound insomnia when it is stopped. Ramelteon was approved by the FDA in July 1995.




Tablets: 8 mg

STORAGE: Ramelteon should be store at room temperature, between 15-30 C (59-86 F).

PRESCRIBED FOR: Ramelteon is used for improving sleep in individuals who have insomnia that involves difficulty falling asleep.

DOSING: The recommended dose of ramelteon is 8 mg taken 30 minutes before bedtime. Ramelteon should not be taken with or immediately after a high fat meal because fat increases its absorption from the intestine.

DRUG INTERACTIONS: Doxepin (Sinequan, Adapin), donepezil (Aricept), fluvoxamine (Luvox, Luvox CR), ketoconazole (Nizoral, Extina, Xolegel, Kuric), and fluconazole (Sporanox) increase blood levels of ramelteon, possibly increasing side effects of ramelteon. Rifampin may decrease blood levels of ramelteon, possibly reducing the effect of ramelteon. Alcohol increases the sedative effects ramelteon.

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