Avandamet (rosiglitazone/metformin) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:
>

DRUG INTERACTIONS:

Rosiglitazone is extensively metabolized or broken down by a group of liver enzymes known as CYP2C8. Gemfibrozil (Lopid), a known inhibitor of CYP2C8 may increase blood levels of rosiglitazone and consequently increase the risk of side effects. Concomitant use of agents that also inhibit CYP2C8 requires a reduction in the dose of rosiglitazone.

Rifampin (Rimactane or Rifadin), a known inducer of CYP2C8, increases the breakdown of rosiglitazone. Therefore, concomitant use of agents that induce CYP2C8 may decrease the effectiveness of rosiglitazone.

Drugs which cause blood glucose levels to increase may diminish the effectiveness of Avandamet therapy. These drugs include

PREGNANCY: Avandamet has not been adequately evaluated in pregnant women. Due to the lack of conclusive safety data, Avandamet should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Avandamet is classified as FDA pregnancy risk category C.

NURSING MOTHERS: It is not known if Avandamet is excreted in breast milk. Due to the lack of safety data, Avandamet is not recommended for use in nursing mothers.

REFERENCE: FDA Prescribing Information


Medically Reviewed by a Doctor on 8/20/2015


Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.


Back to Medications Index