Avandamet (rosiglitazone/metformin)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Type 2 Diabetes Warning Signs

PRESCRIPTION: Yes

GENERIC AVAILABLE: No

PREPARATIONS: Oral tablets containing Avandamet: 2/500, 4/500, 2/1,000, and 4/1,000 mg.

STORAGE: Tablets should be stored at room temperature, between 15 C and 30 C (59 F and 86 F). Tablets should be dispensed and stored in an air-tight, light-resistant container.

DOSING: The dosage of Avandamet should be individualized based on patient response and tolerability. It is generally given in divided doses with meals.

For patients inadequately controlled on diet and exercise

  • Generally, the recommended starting dose of Avandamet is 2/500 mg administered once or twice daily.
  • A starting dose of 2/500 mg twice daily may be considered for patients with HbA1c >11% or fasting plasma glucose (FPG) >270 mg//dL.
  • If patients are not adequately controlled after 4 weeks of treatment the dosage may be increased in increments of 2/500 mg as necessary.
  • The maximum daily dose of Avandamet is 8/2,000 mg.

For patients inadequately controlled on rosiglitazone or metformin monotherapy

  • The selection of the dose of Avandamet must be based on the patient's current doses of rosiglitazone and/or metformin.
  • To switch to Avandamet for patients currently treated with metformin
  • The usual starting dose of Avandamet is 4 mg rosiglitazone and base the metformin dose on the current dose of metformin.
  • To switch to Avandamet for patients currently treated with rosiglitazone
  • The usual starting dose of Avandamet is 1,000 mg metformin and the corresponding dose of rosiglitazone that the patient is taking.

The safety and efficacy of Avandamet has not been established in pediatric patients. Therefore, use of Avandamet in this patient population is not recommended.

Medically Reviewed by a Doctor on 8/20/2015

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