GENERIC NAME: rosiglitazone/metformin
BRAND NAME: Avandamet
DRUG CLASS AND MECHANISM: Avandamet is a combination antidiabetic medication that contains rosiglitazone and metformin. It is used with diet and exercise to improve blood glucose (sugar) control in adults with type 2 diabetes.
In Avandamet, rosiglitazone and metformin work by two different mechanisms to improve blood glucose control. Rosiglitazone which is a selective and potent agonist of the peroxisome proliferator activated receptor-gamma (PPAR?) improves insulin sensitivity (helps your body respond more to insulin already present in the body). Metformin increases insulin sensitivity but also decreases the production of glucose in the liver, decreases the absorption of glucose by the intestines, and increases the peripheral uptake and use of glucose in the blood. Avandamet can be prescribed alone or used with other anti-diabetic medications.
In clinical trials, statistically significant improvements in fasting blood glucose, glycosylated hemoglobin (HbA1c) and insulin sensitivity were observed when rosiglitazone 4 mg or 8 mg daily was added to existing metformin therapy. Furthermore, Avandamet therapy was shown to be superior to either drug alone in improving fasting blood glucose concentrations and HbA1c in patient who have not received other drugs. Avandamet was approved by the FDA in October, 2002.
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