rosiglitazone, Avandia (cont.)

Pharmacy Author:
Pharmacy Author:
Medical and Pharmacy Editor:

Gemfibrozil (Lopid) increases the concentration of rosiglitazone in the blood by reducing its breakdown in the liver. Therefore, rosiglitazone may increase the side effects of rosiglitazone.

Rosiglitazone should not be combined with nitrates (for example, isosorbide dinitrate [Isordil Titradose, Dilatrate-SR, Isochron]). In clinical trials, the risk of chest pain and heart attacks was greater in individuals on nitrate therapy.

PREGNANCY: There are no adequate studies of rosiglitazone in pregnant women. Rosiglitazone crosses the placenta and is detectable in fetal tissue.

NURSING MOTHERS: It is unknown if rosiglitazone is secreted in breast milk. Therefore, the safety of rosiglitazone to nursing infants also is unknown.

Medically reviewed by Eni Williams, PharmD

Reference: FDA Prescribing Information for Avandia.


Medically Reviewed by a Doctor on 12/18/2014


Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.


Back to Medications Index