rosiglitazone, Avandia (cont.)

Pharmacy Author:
Pharmacy Author:
Medical and Pharmacy Editor:

SIDE EFFECTS AND PRECAUTIONS: The most common side effects seen with rosiglitazone alone or in combination with metformin are:

Rosiglitazone has been shown to cause mild to moderate accumulation of fluid (edema) and can lead to heart failure. Patients who already have heart failure may develop worsening symptoms with rosiglitazone. Therefore, rosiglitazone should not be used by patients with heart failure. Rosiglitazone also has been associated with an increased risk of chest pain and heart attacks. The risk of heart attacks may be greater in those with established heart disease and taking nitrates or individuals receiving insulin.

Other important side effects include:

  • anemia with rosiglitazone alone or combined with metformin.
  • weight gain, and
  • Increased risk of bone fractures in women who received rosiglitazone for 4 to 6 years.

GENERIC AVAILABLE: No

PRESCRIPTION: Yes

PREPARATIONS: Tablets: 2, 4, and 8 mg.

STORAGE: Tablets should be kept at room temperature, 15 C -30 C (59 F -86 F).

DOSING: Rosiglitazone may be taken once or twice daily, with or without meals. Daily doses range from 4 to 8 mg either with or without other antidiabetic medications. There is no additional benefit for doses greater than 8 mg per day.

DRUG INTERACTIONS: Rifampin decreases concentrations in the blood of rosiglitazone by increasing its breakdown in the liver. Therefore, use of rifampin may decrease the effectiveness of rosiglitazone.

Medically Reviewed by a Doctor on 12/18/2014


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