rosiglitazone, Avandia (cont.)

Pharmacy Author:
Pharmacy Author:
Medical and Pharmacy Editor:

Rosiglitazone has been shown to cause mild to moderate accumulation of fluid (edema) and can lead to heart failure. Patients who already have heart failure may develop worsening symptoms with rosiglitazone. Therefore, rosiglitazone should not be used by patients with heart failure. Rosiglitazone also has been associated with an increased risk of chest pain and heart attacks. The risk of heart attacks may be greater in those with established heart disease and taking nitrates or individuals receiving insulin.

In addition, anemia may occur with rosiglitazone alone or combined with metformin. Rosiglitazone also causes increasing amounts of weight gain with increasing doses. Increased risk of bone fractures has been observed in women who received rosiglitazone for 4 to 6 years.

Reference: FDA Prescribing Information for Avandia.


Last Editorial Review: 9/28/2010



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