SIDE EFFECTS AND PRECAUTIONS: The most common side effects seen with rosiglitazone alone or in combination with metformin are:
- upper respiratory tract infection,
- back pain,
- hyperglycemia (elevated blood sugar),
- diarrhea, and
- hypoglycemia (low blood sugar).
Rosiglitazone has been shown to cause mild to moderate accumulation of fluid (edema) and can lead to heart failure. Patients who already have heart failure may develop worsening symptoms with rosiglitazone. Therefore, rosiglitazone should not be used by patients with heart failure. Rosiglitazone also has been associated with an increased risk of chest pain and heart attacks. The risk of heart attacks may be greater in those with established heart disease and taking nitrates or individuals receiving insulin.
Other important side effects include:
- anemia with rosiglitazone alone or combined with metformin.
- weight gain, and
- Increased risk of bone fractures in women who received rosiglitazone for 4 to 6 years.
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