ropinirole (Requip, Requip XL) (cont.)

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Parkinson's disease

Immediate-release tablets: Take 0.25 mg by mouth 3 times a day for week 1, then increase weekly by 0.25 mg 3 times a day if needed. After week 4 doses may be increased by 1.5 mg/day on weekly basis up to a dose of 9 mg/day. If still needed, may increase doses by 3 mg/day on a weekly basis to a total dose of 24 mg/day.

Extended-release tablets: Take 2 mg by mouth once daily for 1 to 2 weeks. Doses can be increased by 2 mg/day at intervals longer than week. Not to exceed 24 mg/day.

Restless Leg Syndrome (RLS)

Immediate release tablets: Take 0.25 mg by mouth 1 to 3 hours before bedtime on day 1 and 2. Starting day 3 to 7, may increase to 0.5 mg by mouth once daily at bedtime. Starting week 2, may increase to 1 mg per day, then increase weekly by 0.5 mg/day to up to 4 mg/day.

DRUG INTERACTIONS: Ropinorole should not be used with phenothiazine, atypical antipsychotics. and metoclopramide (Reglan) because these drugs block dopamine receptors and lead to decreased effectiveness of ropinorole. Examples of phenothiazines include prochlorperazine (Compazine), fluphenazine (Permitil), and trifluoperazine (Stelazine). Examples of atypical antipsychotics include aripiprazole (Abilify), olanzapine (Zyprexa), quetiapine (Seroquel), and rispepridone (Risperdal).

Medically Reviewed by a Doctor on 10/3/2014

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