ropinirole (Requip, Requip XL)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jerry R. Balentine, DO, FACEP
    Jerry R. Balentine, DO, FACEP

    Jerry R. Balentine, DO, FACEP

    Dr. Balentine received his undergraduate degree from McDaniel College in Westminster, Maryland. He attended medical school at the Philadelphia College of Osteopathic Medicine graduating in1983. He completed his internship at St. Joseph's Hospital in Philadelphia and his Emergency Medicine residency at Lincoln Medical and Mental Health Center in the Bronx, where he served as chief resident.

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What is ropinirole-oral, and how does it work (mechanism of action)?

Ropinorole is an anti-Parkinson's medication. Ropinorole works by binding to dopamine receptors in the brain. Ropinorole stimulates the dopamine receptors and improves symptoms of Parkinson's disease. The FDA approved ropinirole in September 1997. It is also a treatment for Restless legs syndrome (RLS ).

What brand names are available for ropinirole-oral?

Requip, Requip XL

Is ropinirole-oral available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for ropinirole-oral?

Yes

Quick GuideRLS Remedies in Pictures: Home Care for Better Sleep

RLS Remedies in Pictures: Home Care for Better Sleep

What is the dosage for ropinirole-oral?

Parkinson's disease

Immediate-release tablets: Take 0.25 mg by mouth 3 times a day for week 1, then increase weekly by 0.25 mg 3 times a day if needed. After week 4 doses may be increased by 1.5 mg/day on weekly basis up to a dose of 9 mg/day. If still needed, may increase doses by 3 mg/day on a weekly basis to a total dose of 24 mg/day.

Extended-release tablets: Take 2 mg by mouth once daily for 1 to 2 weeks. Doses can be increased by 2 mg/day at intervals longer than week. Not to exceed 24 mg/day.

Restless Leg Syndrome (RLS)

Immediate release tablets: Take 0.25 mg by mouth 1 to 3 hours before bedtime on day 1 and 2. Starting day 3 to 7, may increase to 0.5 mg by mouth once daily at bedtime. Starting week 2, may increase to 1 mg per day, then increase weekly by 0.5 mg/day to up to 4 mg/day.

Which drugs or supplements interact with ropinirole-oral?

Ropinorole should not be used with phenothiazine, atypical antipsychotics. and metoclopramide (Reglan) because these drugs block dopamine receptors and lead to decreased effectiveness of ropinorole. Examples of phenothiazines include prochlorperazine (Compazine), fluphenazine (Permitil), and trifluoperazine (Stelazine). Examples of atypical antipsychotics include aripiprazole (Abilify), olanzapine (Zyprexa), quetiapine (Seroquel), and rispepridone (Risperdal).

Ropinorole should be used with caution with ciprofloxacin (Cipro) because ciprofloxacin slows down the breakdown of ropinorole, which leads to increased ropinorole levels in the body.

Is ropinirole-oral safe to take if I'm pregnant or breastfeeding?

There are no adequate studies of ropinorole to determine safe and effective use in pregnant women.

It is not known whether ropinorole enters breast milk. It is should be avoided in nursing mothers to avoid potential risks to newborn infants.

SIDE EFFECTS: Patients treated with ropinirole have reported falling asleep during activities of daily living, including driving. Other side effects of ropinorole are nausea, flatulence, dizziness, sleepiness, fatigue, flushing, hallucinations, confusion, irregular heart rate and rhythm, and confusion.

What else should I know about ropinirole-oral?

What preparations of ropinirole-oral are available?

Tablets (immediate release): 0.25, 0.5, 1, 2, 3, 4, 5 mg. Tablets (extended-release): 2, 4, 6, 8, 12 mg

How should I keep ropinirole-oral stored?

STORAGE Store ropinorole immediate-release and extended-release tablets between temperatures 15 C and 30 C (59 F and 86 F).

REFERENCE: FDA Prescribing Information.

Quick GuideRLS Remedies in Pictures: Home Care for Better Sleep

RLS Remedies in Pictures: Home Care for Better Sleep

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Reviewed on 10/3/2014
References
REFERENCE: FDA Prescribing Information.

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