GENERIC NAME: ropinorole hydrochloride
BRAND NAME: Requip, Requip XL
DRUG CLASS AND MECHANISM: Ropinorole is an anti-Parkinson's medication. Ropinorole works by binding to dopamine receptors in the brain. Ropinorole stimulates the dopamine receptors and improves symptoms of Parkinson's disease. The FDA approved ropinirole in September 1997. It is also a treatment for Restless legs syndrome (RLS ).
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets (immediate release): 0.25, 0.5, 1, 2, 3, 4, 5 mg. Tablets (extended-release): 2, 4, 6, 8, 12 mg
STORAGE Store ropinorole immediate-release and extended-release tablets between temperatures 15 C and 30 C (59 F and 86 F).
Immediate-release tablets: Take 0.25 mg by mouth 3 times a day for week 1, then increase weekly by 0.25 mg 3 times a day if needed. After week 4 doses may be increased by 1.5 mg/day on weekly basis up to a dose of 9 mg/day. If still needed, may increase doses by 3 mg/day on a weekly basis to a total dose of 24 mg/day.
Extended-release tablets: Take 2 mg by mouth once daily for 1 to 2 weeks. Doses can be increased by 2 mg/day at intervals longer than week. Not to exceed 24 mg/day.
Restless Leg Syndrome (RLS)
Immediate release tablets: Take 0.25 mg by mouth 1 to 3 hours before bedtime on day 1 and 2. Starting day 3 to 7, may increase to 0.5 mg by mouth once daily at bedtime. Starting week 2, may increase to 1 mg per day, then increase weekly by 0.5 mg/day to up to 4 mg/day.
DRUG INTERACTIONS: Ropinorole should not be used with phenothiazine, atypical antipsychotics. and metoclopramide (Reglan) because these drugs block dopamine receptors and lead to decreased effectiveness of ropinorole. Examples of phenothiazines include prochlorperazine (Compazine), fluphenazine (Permitil), and trifluoperazine (Stelazine). Examples of atypical antipsychotics include aripiprazole (Abilify), olanzapine (Zyprexa), quetiapine (Seroquel), and rispepridone (Risperdal).
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