rivaroxaban (Xarelto)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is rivaroxaban, and how does it work (mechanism of action)?

Xarelto is an oral anticoagulant (blood thinner) that is used to prevent and treat blood clots. Blood clots formed in the heart are dangerous since they can travel to the brain and cause a stroke. Similarly, blood clots formed in the legs or lungs can be equally life threatening if not treated. Xarelto is a selective inhibitor of factor Xa, an enzyme necessary to form blood clots. It reduces the ability of blood to clot. The FDA approved Xarelto in July, 2011.

What brand names are available for rivaroxaban?

Xarelto

Is rivaroxaban available as a generic drug?

GENERIC AVAILABLE: No

Do I need a prescription for rivaroxaban?

Yes

What are the uses for rivaroxaban?

Xarelto is a prescription medicine used to:

What are the side effects of rivaroxaban?

The most common side effect of Xarelto is bleeding. The risk of bleeding is higher when Xarelto is taken with medicines such as aspirin or aspirin-containing products, nonsteroidal anti-inflammatory drugs (NSAIDS), warfarin (Coumadin, Jantoven), heparin, clopidogrel (Plavix), and other medicines used to prevent or treat blood clots.

Some rare but serious cases of bleeding and paralysis have been reported with the use of Xarelto in patients undergoing spinal or epidural procedures. Risk is highest in patients who have problems with their spine, use indwelling epidural catheters, have had spinal surgery, or use other medicines that prevent clotting or make them more likely to bleed.

Other common side effects of Xarelto include:

Serious side effects of Xarelto include:

Medically Reviewed by a Doctor on 6/16/2016

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