ritonavir, Norvir (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
Ritonavir should be administered with meals. The taste of the oral solution can be improved by mixing it with chocolate milk, Ensure or Advera for up to one hour before administration.
DRUG INTERACTIONS: Ritonavir interacts with many drugs. Some of the important interactions are mentioned below. Viewers should consult their healthcare provider before combining any drugs with ritonavir.
Ritonavir should not be used together with amiodarone (Cordarone), quinidine (Quinaglute, Cardioquin), triazolam (Halcion), midazolam (Versed), pimozide (Orap), ergot derivatives (for example, ergotamine, dihydroergotamine), alfuzosin (Uroxatral), propafenone (Rythmol) and flecainide (Tambocor) because ritonavir increases the blood levels of these drugs and may lead to serious side effects. Ritonavir should not be combined with voriconazole (Vfend) because it reduces blood levels of voriconazole.
Ritonavir also increases the concentrations in blood of rifabutin (Mycobutin) and sildenafil (Viagra). Therefore, the doses of rifabutin and sildenafil should be reduced. The blood concentrations of oral contraceptives, methadone (Dolophine) and theophylline (Theo-Dur, Theo-24) are reduced by ritonavir, and this could reduce the effectiveness of these drugs.
Ritonavir decreases the concentration of meperidine (Demerol) and increases the buildup of meperidine's toxic breakdown product in the body. Therefore, ritonavir reduces the beneficial effect of meperidine while increasing its side effects.
Ritonavir may increase the blood concentration of lovastatin (Mevacor), simvastatin (Zocor), and atorvastatin (Lipitor). This may result in increased occurrence of myopathy (muscle pain) or rhabdomyolysis (muscle breakdown). Lovastatin and simvastatin should not be combined with ritonavir.
Medically Reviewed by a Doctor on 7/23/2015
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