ritonavir, Norvir (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PRESCRIBED FOR: Ritonavir is used in combination with other drugs for the treatment of HIV infection.

SIDE EFFECTS: The most serious side effects are:

  • liver failure,
  • inflammation of the pancreas (pancreatitis),
  • heart block, and
  • severe allergic reactions.

Ritonavir also may elevate blood glucose resulting in new onset diabetes. Fat redistribution, elevated triglycerides, and elevated cholesterol levels also occur. Patients with hemophilia may experience spontaneous bleeding. Immune reconstitution syndrome which is an inflammatory response to infection may occur in patients treated with combination antiretroviral therapy.

Other important side effects include:



PREPARATIONS: Capsules or tablets: 100 mg; Solution: 80 mg/ml

STORAGE: Capsules that will not be used within 30 days should be stored in a refrigerator between 2 C to 8 C (36 F to 46F). Capsules that will be used within 30 days do not have to be refrigerated if stored at less than 25 C (77 F) Oral solution should be stored at room temperature, 20 C to 25 C (68 F to77 F).

DOSING: The recommended dose for adults is 600 mg twice daily. To reduce the occurrence of side effects, ritonavir should be started at 300 mg twice daily and increased every 2-3 days by 100 mg twice daily.

The recommended dose for children older than 1 month is 350 to 400 mg/m2 two times a day and should not exceed 600 mg two times daily. Treatment should be started at 250 mg/m2 and increased every 2-3 days by 50 mg/m2 two times daily.

Medically Reviewed by a Doctor on 7/23/2015

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