risedronate, Actonel, Atelvia (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
STORAGE: Tablets should be stored at room temperature, 15-30 C (59-86 F).
PRESCRIBED FOR: Risedronate is used for the treatment of Paget's disease of bone (osteitis deformans), treatment and prevention of postmenopausal osteoporosis in women, and treatment of osteoporosis in men. It also is used to prevent and treat osteoporosis caused by steroid medications (glucocorticoid-induced osteoporosis).
Risedronate should be taken with 6 to 8 ounces of plain water. Because food interferes with the absorption of risedronate, it should be taken first thing in the morning before anything is eaten or liquids consumed. Also, no food or drink should be taken for at least 30 minutes after taking risedronate. To avoid pills sticking and irritating the throat or esophagus, persons should not lie down for at least 30 minutes after taking risedronate. It also should not be taken at the same time as iron supplements, vitamins with minerals, or antacids containing calcium, magnesium, or aluminum which reduce the absorption of risedronate.
DRUG INTERACTIONS: Food, calcium, antacids, and medications containing iron, magnesium, or aluminum reduce the absorption of risedronate, resulting in loss of effectiveness. Thus, it should be taken with plain water only.
PREGNANCY: The safety and effectiveness of risedronate has not been established in pregnant women. Physicians must therefore weigh the potential benefits and unknown risks carefully.
NURSING MOTHERS: The safety of risedronate for the infant has not been established in women who breastfeeding.
SIDE EFFECTS: The most common side effects of risedronate are headache, joint pain, diarrhea, abdominal pain, rash, high blood pressure, and nausea. Severe irritation of the esophagus (for example, esophagitis, esophageal ulcers, esophageal erosions) can occur. This occurs more often when patients do not drink enough water with risedronate, or do not wait 30 minutes before lying down. Rarely, patients may experience jaw problems (osteonecrosis of the jaw) associated with delayed healing and infection after tooth extraction.
Reference: FDA Prescribing Information
Last Editorial Review: 3/28/2012
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