Medications and Drugs
GENERIC NAME: risedronate
BRAND NAME: Actonel
DRUG CLASS AND MECHANISM: Risedronate is in a class of drugs called bisphosphonates which also includes the drugs alendronate (Fosamax) and etidronate (Didronel). It is used for the treatment of Paget's disease of bone (a disease in which the formation of bone is abnormal) and in persons with osteoporosis (in which the density and strength of bones are reduced). Bone is continually being formed and dissolved. By slowing down the rate at which bone is dissolved, risedronate increases the amount of bone. Risedronate has a chemically unique component as compared with the other bisphosphonates which is believed to reduce the likelihood of gastro-intestinal side effects. Risedronate is more potent in blocking the dissolution of bone than etidronate and alendronate. The FDA approved risedronate for treatment of Paget's disease in 1998 and for the prevention and treatment of osteoporosis in 1999.
GENERIC AVAILABLE: no
PRESCRIPTION: yes
PREPARATIONS: Tablets of 5, 30, and 35 mg.
STORAGE: Tablets should be stored at room temperature,
15-30 °C (59-86 °F).
PRESCRIBED FOR: Risedronate is used for the treatment of Paget's
disease of bone (osteitis deformans) and to treat or prevent osteoporosis. It is also used to prevent and treat osteoporosis that is caused by cortisone-related medications (glucocorticoid-induced osteoporosis).
DOSING: For osteoporosis, 5 mg of risedronate is taken once daily or 35 mg is taken weekly with 6 to 8
ounces of plain water. For Paget's disease, initial treatment is 30 mg daily for two months. Because food interferes with the absorption of
risedronate, it should be taken first thing in the morning before anything
is eaten or drunk. Also, no food or drink should be taken for at least
30 minutes afterwards. To avoid pills sticking and irritating the throat or esophagus, persons should not lie down for at least 30 minutes after taking risedronate. It should also not be taken at the same time as iron supplements, vitamins with minerals, or antacids containing calcium, magnesium, or aluminum.
DRUG INTERACTIONS: Food, calcium and other minerals reduces the absorption of risedronate, resulting in loss of effectiveness. Thus, it should be taken with plain water only.
PREGNANCY: The safety and effectiveness of risedronate has not
been established in pregnant women. Physicians must therefore weigh the potential benefits and unknown risks carefully.
NURSING MOTHERS: The safety and effectiveness of risedronate has
not been established in women who are nursing.
SIDE EFFECTS: Risedronate generally is well-tolerated. The most
common side effects are headache (1 in 5 persons), joint pain (1 in 3),
diarrhea (1 in 5), abdominal pain (1 in 9), rash (1 in 9), and nausea (1 in
10). A related drug, alendronate, can irritate the esophagus and cause
heartburn in patients when it sticks in the esophagus.
Reference: FDA Prescribing Information
Last Editorial Review: 3/2/2003
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
- Drug Interactions - Learn about potential drug interactions you may be exposed to. Drug interactions can occur with prescription drugs, OTC medication, vitamins, herbs, and supplements.
- Osteoporosis - Get information on osteoporosis causes, symptoms, diagnosis, treatment (drugs), prevention (diet, weight-bearing exercise), statistics, risk factors (hereditary) and research.
- Drugs: What You Should Know About Your Drugs - Find out what you should know about your drugs such as side effects, warnings and precautions, storage information, and if a generic version is as good as the brand name.
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