sodium chloride, potassium chloride, sodium lactate and calcium (Lactated Ringer's Solution)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

PREPARATIONS: Lactated Ringer's solution is available in 250 ml, 500 ml, and 1000 ml in specific plastic containers.

  • Lactated Ringer's is composed of sodium chloride 6 g/L, sodium lactate 3.1 g/L, potassium chloride 0.3 g/L, and calcium chloride 0.2 g/L.
  • Lactated Ringer's contains ions of sodium 130 mEq/L, potassium 4 mEq/L, calcium 2.7 mEq/L, chloride 109 mEq/L, and lactate 28 mEq/L.
  • Lactated Ringer's has an osmolarity of 273 mOsmol/L, pH of 6.5, and caloric content of 9 kcal/L.

DRUG INTERACTIONS: Lactated Ringer's solution should not be mixed with ceftriaxone (Rocephin) due to the significant risk of ceftriaxone and calcium precipitation.

PREGNANCY AND BREASTFEEDING SAFETY: There are no adequate studies done on Lactated Ringer's solution to determine safe and effective use in pregnant women.

Use by women who are breastfeeding mothers has not been adequately evaluated.

STORAGE: Store Lactated Ringer's solution at room temperature of 25 C, avoiding excessive heat. Brief exposure to up to 40 C does not affect the product.

DOSAGE: Adult dosing of Lactated Ringer's solution is as directed by the physician. Dosing is individualized based on the patient's age, weight, ongoing treatment, and clinical condition.

Safe and effective use of Lactated Ringer's solution in children is based on clinical practice.

DRUG CLASS AND MECHANISM: Lactated Ringer's is a sterile solution for fluid and electrolyte replenishment. It restores fluid and electrolyte balances, produces diuresis, and acts as alkalizing agent (reduces acidity). The FDA approved Ringer's solution in plastic containers in 1971.

Medically reviewed by Eni Williams, PharmD, PhD

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 8/2/2016

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