sodium chloride, potassium chloride, sodium lactate and calcium (Lactated Ringer's Solution)

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GENERIC NAME: sodium chloride, potassium chloride, sodium lactate and calcium chloride

BRAND NAME: Lactated Ringer's solution

DRUG CLASS AND MECHANISM: Lactated Ringer's is a sterile solution for fluid and electrolyte replenishment. It restores fluid and electrolyte balances, produces diuresis, and acts as alkalizing agent (reduces acidity). The FDA approved Ringer's solution in plastic containers in 1971.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Lactated Ringer's solution is available in 250 ml, 500 ml, and 1000 ml in specific plastic containers.

  • Lactated Ringer's is composed of sodium chloride 6 g/L, sodium lactate 3.1 g/L, potassium chloride 0.3 g/L, and calcium chloride 0.2 g/L.
  • Lactated Ringer's contains ions of sodium 130 mEq/L, potassium 4 mEq/L, calcium 2.7 mEq/L, chloride 109 mEq/L, and lactate 28 mEq/L.
  • Lactated Ringer's has an osmolarity of 273 mOsmol/L, pH of 6.5, and caloric content of 9 kcal/L.

STORAGE: Store Lactated Ringer's solution at room temperature of 25 C, avoiding excessive heat. Brief exposure to up to 40 C does not affect the product.

PRESCRIBED FOR: Lactated Ringer's is used for balancing fluid and electrolytes and as an alkalizing agent.

DOSING: Adult dosing of Lactated Ringer's solution is as directed by the physician. Dosing is individualized based on the patient's age, weight, ongoing treatment, and clinical condition.

Safe and effective use of Lactated Ringer's solution in children is based on clinical practice.

DRUG INTERACTIONS: Lactated Ringer's solution should not be mixed with ceftriaxone (Rocephin) due to the significant risk of ceftriaxone and calcium precipitation.

PREGNANCY: There are no adequate studies done on Lactated Ringer's solution to determine safe and effective use in pregnant women.

NURSING MOTHERS: Use by women who are breastfeeding mothers has not been adequately evaluated.

SIDE EFFECTS: Side effects of Lactated Ringer's solution are chest pain, abnormal heart rate, decreased blood pressure, troubled breathing, cough, sneezing, rash, itching, and headache. Infection at the site of injection, venous thrombosis or phlebitis at the site of injection, extravasation, and increased fluid volume (hypervolemia) may also occur.

REFERENCE: FDA Prescribing Information.


Medically Reviewed by a Doctor on 6/26/2014



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