rimantadine, Flumadine

  • Pharmacy Author:
    Eni Williams, PharmD, PhD

    Dr. Eni Williams graduated from Creighton University in 1988 with a B.S. degree in pharmacy and a Doctor of Pharmacy from Howard University in 1994. She also obtained a Ph.D. in Public Policy in 2009 at the University of Maryland, Baltimore County.

  • Pharmacy Author: Omudhome Ogbru, PharmD
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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GENERIC AVAILABLE: Yes

PRESCRIPTION: Yes

PREPARATIONS: Tablets: 100 mg. Syrup: 50 mg per teaspoonful.

STORAGE: Tablets and syrup should be stored at room temperature, between 15 C and 30 C (59 F and 86 F).

DOSING: The dose of rimantadine in adults for both prevention and treatment of the influenza virus infection is one, 100 mg tablet taken twice daily with or without food. If it causes an upset stomach, it can be taken with food. The usual dose of rimantadine for prevention of the influenza virus in children is 5 mg/kg daily given in two divided doses. If used for treatment of an established infection, rimantadine should be started as soon as possible, preferably within 48 hours after the onset of symptoms. It should be continued for 5 to 7 days from when symptoms began and stopped soon after symptoms disappear.

DRUG INTERACTIONS: Rimantadine may reduce the effectiveness of influenza virus vaccine. It is recommended that rimantadine not be given 48 hours prior to and 14 days after administering the influenza virus vaccine. Rimantadine may interact with monoamine oxidase inhibitors (MAOIs), for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane), and cause the blood pressure to drop suddenly.

PREGNANCY: There are no well-controlled studies of rimantadine in pregnant women and, therefore, rimantadine is not recommended during pregnancy. Other drugs including oseltamivir (Tamiflu) and zanamivir (Relenza) are recommended for the prevention and treatment of influenza A virus illness in pregnant women.

NURSING MOTHERS: It is not recommended that mothers who are breastfeeding use rimantadine due to possible risks of adverse effects in infants.

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 1/12/2015

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