USES: This medication is used in the treatment of tuberculosis or other infections when the oral form cannot be taken. Use of only rifampin and pyrazinamide as a two-drug, two-month therapy to treat tuberculosis (specifically "latent" TB infection) is no longer recommended. Infrequently, serious (sometimes fatal) liver disease has occurred with the use of these two drugs alone. Several other effective alternative treatments can be used to treat latent tuberculosis (e.g., isoniazid for 9 months). Use of rifampin and pyrazinamide as part of a multi-drug (3 or more drugs) treatment plan for tuberculosis is still acceptable. Consult your doctor or pharmacist for more details.
HOW TO USE: This medication is given by injection into a vein usually once or twice a day. Avoid injecting intramuscularly or subcutaneously. Inject into a vein only. This medication must be used as prescribed. Do not skip doses or stop using this without your doctor's approval. Stopping therapy too soon may result in ineffective treatment. Full course of therapy may take several months or longer to complete.
SIDE EFFECTS: Sore mouth, drowsiness, dizziness or flushing may occur the first several days as your body adjusts to the medication. If any of these effects continue or become bothersome, inform your doctor. Tell your doctor immediately if any of these unlikely but serious side effects occur: weakness, unusual bruising or bleeding, flu-like symptoms (fever, chills, headache, muscle ache), nausea, vomiting, stomach pain, dark urine, yellowing of the eyes or skin, pale stools, numbness or tingling of the hands or feet, changes in vision, confusion, memory trouble, sore throat. This medication may cause urine, saliva, tears, stools and sweat to turn red-orange in color. Do not be alarmed. This will disappear when the medication is stopped. Notify your doctor if the injection site becomes swollen or irritated. Another injection site may be necessary. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis bacteria. Symptoms include weakness, fever, weight loss, night sweats and in worse cases, chest pain, shortness of breath, and coughing up blood. A person with an active infection (a positive TB skin test, abnormal chest x-ray and TB bacteria in their sputum) requires treatment with izoniazid, rifampin, ethambutol and pyrazinaide.
Leprosy (Hansen's disease) is a disfiguring disease caused by infection with Mycobacterium leprae bacteria. The disease is spread from person to person through nasal secretions or droplets. Symptoms and signs of leprosy include numbness, loss of temperature sensation, painless ulcers, eye damage, loss of digits, and facial disfigurement. Leprosy is treated with antibiotics and the dosage and length of time of administration depends upon which form of leprosy the patient has.
Brucellosis is an infectious disease caused by the Brucella bacteria. Symptoms and signs include sweating, fever, fatigue, dizziness, headache, cough, chest, joint, and abdominal pain, and enlarged liver and/or spleen. Brucellosis is treated with antibiotics.
Legionellosis is an infection caused by the Legionella pneumophila bacterium. There are two forms of legionellosis: Pontiac fever and Legionnaires' disease, which is the more severe of the two infections. Symptoms of Pontiac fever include fever, headache, muscle aches, and chills. Symptoms of Legionnaires' disease include cough, chills, fever and sometimes muscle aches, headaches, loss of appetite, diarrhea, and severe pneumonia. While Pontiac fever resolves on its own, Legionnaires' disease must be treated with antibiotics.
Brucellosis is an infectious disease caused by bacteria from the genus
Brucella. It is an infection that affects mainly animals, including goats, sheep,
camels, pigs, elk, deer, cattle, and dogs. Humans develop brucellosis when they
come in contact with contaminated animals or animal products. The symptoms of
brucellosis often resemble a flu-like illness.
Human brucellosis is a disease that is found worldwide, and it has an annual
occurrence rate of more than 500,000 cases. Brucellosis tends to occur more
commonly in regions with less established animal-disease-control programs and
in areas where public-health initiatives may be less effective. High-risk areas
include the Mediterranean Basin (Portugal, Spain, Southern France, Italy,
Greece, Turkey, and North Africa), South and Central America, Eastern Europe,
Africa, Asia, the Caribbean, and the Middle East. In the United States,
brucellosis is much less common, wi...
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