ribavirin, Rebetol, Copegus, Ribasphere, RibaPak, Moderiba (cont.)

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PREPARATIONS: Capsule: 200 mg.

STORAGE: Ribavirin should be refrigerated at 2 C to 8 C (36 F to 46 F).


  • Ribavirin dosing is individualized based upon a patient's weight and previous use of interferon.
  • Dosing also depends on the formulation used and the type of hepatitis C virus infection.
  • The recommended dose of ribavirin tablets is 800 to 1200 mg divided every 12 hours for 24 to 48 weeks.
  • Ribavirin may be taken with or without food. When taken orally, it should be taken consistently. For example, it should be taken at the same time or times each day and with or without food each time.

DRUG INTERACTIONS: Ribavirin used at the same time as other antiviral drugs with similar mechanisms of action may cause a condition in which lactic acid accumulates in the blood (lactic acidosis) which can lead to serious medical problems. Other such antiviral drugs include those used to manage HIV infection, for example, zidovudine (Retrovir), zalcitabine (Hivid) or stavudine (Zerit).

Adding ribavirin treatment among patients taking azathioprine (Imuran, Azasan) increases the chance of severe pancytopenia (a reduction in the numbers of all types of blood cells) due to azathioprine. This occurs because ribavirin reduces the breakdown of a harmful chemical produced during the breakdown of azathioprine.

PREGNANCY: There are no studies of ribavirin in pregnant women; however, in pregnant animals receiving ribavirin in smaller doses than those given to humans there have been fetal birth defects and death. Therefore, ribavirin should not be taken by pregnant women. In addition, women who are receiving ribavirin therapy should wait at least 6 months after ribavirin is stopped before becoming pregnant in order to prevent potential effects of ribavirin on the fetus.

Medically Reviewed by a Doctor on 1/27/2015

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