ribavirin, Rebetol, Copegus, Ribasphere, RibaPak, Moderiba (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
The most serious side effect seen with ribavirin is anemia. Careful consideration is advised if ribavirin is used in patients with heart or circulation problems since the anemia may aggravate these conditions.
Ribavirin should be avoided among patients who have severe kidney disease and have lost most of their kidneys' function.
Therapy with ribavirin and interferon may aggravate psychiatric conditions or may trigger a psychiatric condition such as depression, psychosis, aggressive behavior, hallucinations, or violent behavior. Patients should be closely monitored for the development of these psychiatric conditions.
Therapy with ribavirin and interferon has caused abnormalities of the thyroid gland. If these abnormalities persist and cannot be controlled by medication, it may be necessary to discontinue therapy.
PREPARATIONS: Capsule: 200 mg.
STORAGE: Ribavirin should be refrigerated at 2 C to 8 C (36 F to 46 F).
DRUG INTERACTIONS: Ribavirin used at the same time as other antiviral drugs with similar mechanisms of action may cause a condition in which lactic acid accumulates in the blood (lactic acidosis) which can lead to serious medical problems. Other such antiviral drugs include those used to manage HIV infection, for example, zidovudine (Retrovir), zalcitabine (Hivid) or stavudine (Zerit).
Adding ribavirin treatment among patients taking azathioprine (Imuran, Azasan) increases the chance of severe pancytopenia (a reduction in the numbers of all types of blood cells) due to azathioprine. This occurs because ribavirin reduces the breakdown of a harmful chemical produced during the breakdown of azathioprine.
Medically Reviewed by a Doctor on 1/27/2015
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