Dr. Nabili received his undergraduate degree from the University of California, San Diego (UCSD), majoring in chemistry and biochemistry. He then completed his graduate degree at the University of California, Los Angeles (UCLA). His graduate training included a specialized fellowship in public health where his research focused on environmental health and health-care delivery and management.
Dr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology.
Rhabdomyolysis (RAB-DOE-MY-O-LIE-SIS) is the rapid destruction of skeletal muscle resulting in
leakage into the urine of the muscle
There are three different types of muscle in the human body;
skeletal muscle is the muscle of movement of the body (moving the skeleton at the joints). Skeletal muscle is affected by
Myoglobin is a protein component of the muscle cells that is released into
the blood when the skeletal muscle is destroyed in rhabdomyolysis.
kinase is an enzyme (a protein that facilitates chemical reactions in the body)
also in the muscle cells. The level of each of these proteins can be
measured in blood to monitor the degree of muscle injury from rhabdomyolysis. Myoglobin can
also be measured in samples of urine.
Rhabdomyolysis (rhabdo=skeleton +myo=muscle + lysis=breakdown)
is a condition in
which muscles break down quickly and spill their contents into the blood stream. Myoglobin is a protein that is contained in muscle cells, and if enough is
spilled into the blood stream, it can clog the kidney's filtering system and
lead to kidney failure and a variety of other serious
medical consequences and complications. While
muscles routinely get sore after physical activity, rhabdomyolysis takes that muscle
injury to a higher level.