Rhabdomyolysis

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Rhabdomyolysis facts

  • Rhabdomyolysis is the rapid destruction of skeletal muscle resulting in leakage into the urine of the muscle protein myoglobin.
  • Rhabdomyolysis has many causes.
  • Medications can cause muscle injury and rhabdomyolysis.
  • Rhabdomyolysis can cause muscle pain and weakness.
  • Blood levels of muscle enzymes, including CPK, SGOT, SGPT, and LDH, as well as blood and urine myoglobin are used to diagnose and monitor rhabdomyolysis.
  • Hospitalization is sometimes required to treat rhabdomyolysis.

What is rhabdomyolysis?

Rhabdomyolysis (RAB-DOE-MY-O-LIE-SIS) is the rapid destruction of skeletal muscle resulting in leakage into the urine of the muscle protein myoglobin.

There are three different types of muscle in the human body;

  1. smooth muscle,
  2. skeletal muscle, and
  3. heart muscle.

The skeletal muscle is the muscle of movement of the body (moving the skeleton at the joints). Skeletal muscle is affected by rhabdomyolysis.

Myoglobin is a protein component of the muscle cells that is released into the blood when the skeletal muscle is destroyed in rhabdomyolysis. Creatine kinase is an enzyme (a protein that facilitates chemical reactions in the body) also in the muscle cells. The level of each of these proteins can be measured in blood to monitor the degree of muscle injury from rhabdomyolysis. Myoglobin can also be measured in samples of urine.

Medically Reviewed by a Doctor on 11/8/2013

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Rhabdomyolysis Symptoms and Causes

Rhabdomyolysis (rhabdo=skeleton +myo=muscle + lysis=breakdown) is a condition in which muscles break down quickly and spill their contents into the blood stream. Myoglobin is a protein that is contained in muscle cells, and if enough is spilled into the blood stream, it can clog the kidney's filtering system and lead to kidney failure and a variety of other serious medical consequences and complications. While muscles routinely get sore after physical activity, rhabdomyolysis takes that muscle injury to a higher level.