Reye Syndrome (cont.)

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What is the prognosis for Reye's syndrome?

There is significant variation in outlook amongst children diagnosed with Reye's syndrome. It is dependent upon the severity and progression of the disease. Some children may have mild disease and completely recover, and others may develop permanent dysfunction of the brain or die from the disease. In general, children who are diagnosed and treated early in the course of the illness have better outcomes. Studies also suggest that those presenting with high ammonia levels have a worse prognosis.

Is it possible to prevent Reye's syndrome?

Although we do not know how to completely prevent Reye's syndrome, we do know that reducing aspirin use in children has resulted in a decrease in the incidence of the illness. In 1980, there were over 500 cases of Reye's syndrome in the United States, and now there are only one to two cases per year. Similar statistics have been seen in the United Kingdom, as well.

What research is being done on Reye's syndrome?

Most research that is being done focuses on understanding what the triggers are for Reye's syndrome and how aspirin is involved in the disease. In addition, some are trying to determine why some patients progress rapidly and some cases simply resolve.

Where can I find more information about Reye's syndrome?

National Reye Syndrome Foundation


Glasgow, J.F. and B. Middleton. "Reye's Syndrome -- Insights on Causation and Prognosis." Arch Dis Child 85.5 (2001): 351-353.

Pugliese, A., T. Beltramo, and D. Torre. "Reye's and Reye's-like Syndromes." Cell Biochem Function 26 (2008): 741-746.

Medically Reviewed by a Doctor on 1/28/2016

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