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February 10, 2012

Reye Syndrome (cont.)

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What is the treatment for Reye's syndrome?

Unfortunately, there is no absolutely effective treatment for Reye's syndrome. Primarily the treatment is aimed at decreasing the effects of the metabolic dysfunction. Patients with Reye's syndrome are admitted to an intensive-care unit and monitored for a worsening neurologic and metabolic condition. The primary goal is to manage electrolyte imbalances and brain swelling. It is difficult to predict which patients will have a progressive illness, however some recommend using medications aimed at lowering the serum ammonia level (ammonia is known be one cause of increased brain swelling). In addition, in some cases of progressive and resistant Reye's syndrome, hemodialysis has also been used to remove toxins believed to be partly responsible for the brain swelling.

What is the prognosis for Reye's syndrome?

There is significant variation in outlook amongst children diagnosed with Reye's syndrome. It is dependent upon the severity and progression of the disease. Some children may have mild disease and completely recover, and others may develop permanent dysfunction of the brain or die from the disease. In general, children who are diagnosed and treated early in the course of the illness have a better outcomes. Studies also suggest that those presenting with high ammonia levels have a worse prognosis.

Can Reye's syndrome be prevented?

Although we do not know how to completely prevent Reye's syndrome, we do know that reducing aspirin use in children has resulted in a decrease in the incidence of the illness. In 1980, there were over 500 cases of Reye's syndrome in the United States, and now there are only one to two cases per year. Similar statistics have been seen in the United Kingdom as well.



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