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February 9, 2012

Reye Syndrome (cont.)

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What are risk factors for Reye's syndrome?

Most children diagnosed with Reye's syndrome have a history of a recent viral infection. Chickenpox and influenza are identified most often, though rotavirus (a cause of bowel inflammation or gastroenteritis) has also been described. In addition to the recent viral infection, most have a history of taking aspirin to control fever. Some researchers have suggested that children with undiagnosed metabolic disorders may also be at risk, though this is not completely clear.

What are Reye's syndrome symptoms and signs?

The primary symptoms of Reye syndrome include uncontrolled vomiting and mental status changes. These symptoms are generally the result of increased intracranial pressure and brain swelling. If untreated and progressive, the disease is fatal. Even if identified and treated early, some patients will still have progressive disease resulting in death or permanent brain damage.

How is Reye's syndrome diagnosed?

The diagnosis of Reye's syndrome is made clinically. That is, it is considered in any child who presents with unexplained brain dysfunction (encephalopathy), vomiting, and liver dysfunction. A history of a recent viral infection and aspirin use certainly supports the diagnosis. In general, laboratory studies that reveal an increase in liver enzymes and ammonia levels and marked decreases in serum glucose (hypoglycemia) are supportive of the diagnosis. However, it should be noted that other metabolic disorders can present with similar symptoms.



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