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February 9, 2012

Reye's Syndrome

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Prevention of Reye's Syndrome

What to Do if You Get the Flu

Medical Author: Melissa Conrad Stoppler, MD
Medical Editor: William C. Shiel Jr., MD, FACP, FACR

The flu is a serious illness that can be fatal in people whose immune systems are weakened, the elderly, and those with chronic medical conditions. Each year 30,000-35,000 people die in the U.S. from the flu or its complications. Even healthy people who develop the flu cannot work, attend school, or participate in normal activities for several days. Complications of the flu can develop in anyone and include pneumonia, ear infections, sinus infections, or bronchitis. These bacterial infections can develop as a complication of the flu because the body's immune system is weakened from the illness.

If you get the flu, there are treatments that can reduce both the intensity and duration of your suffering:

  • Over-the-counter medications such as pain relievers, decongestants, and antihistamines can reduce the severity of your symptoms, but these are not treatments for the viral infection itself. There are over-the-counter flu preparations available that combine these types of medications. (Remember that aspirin should not be given to those under 18 years of age because of its association with Reye syndrome, a serious condition that affects the nervous system and the liver.)

Learn more about flu treatment »


Top Searched Reye's Syndrome Terms:

treatment, aspirin side effects, chickenpox, flu, prognosis

Reye's syndrome facts

  • Reye's syndrome is a rare and severe illness affecting children.
  • Reye's syndrome is associated with viral infection and aspirin use.
  • Patients with Reye's syndrome present with vomiting and mental-status changes.
  • Diagnosing Reye's syndrome primarily depends on the clinical history of symptoms.
  • The most common abnormal laboratory tests with Reye's syndrome include elevated liver enzymes, elevated ammonia levels, and low serum glucose levels.
  • Treatment is supportive, and even with treatment severe cases result in permanent brain damage and death.
  • Since educating parents about the dangers of aspirin use, the incidence of Reye's syndrome has decreased markedly.

What is Reye's syndrome?

Reye's syndrome is a rare but often severe and even fatal illness that primarily occurs in children and adolescents. Children diagnosed with Reye's syndrome generally present with vomiting and mental-status changes. The illness can resolve spontaneously or progress to coma and death. Although the cause is still unclear, studies have identified that there is a relationship between some viral infections and the use of aspirin medications. The CDC recommended educating parents about the dangers of treating children with aspirin in the 1980s, and now the disease occurs very rarely. The syndrome was initially described in 1963 by Dr. Ralph Douglas Reye.

What causes Reye's syndrome?

Although there has been extensive research into the cause of Reye's syndrome, it is still not completely understood. As mentioned above, the use of aspirin or aspirin-containing medications to treat children with some viral infections including chickenpox, influenza, and gastroenteritis has been shown to be associated with the development of the disease. Ultimately, the causes of symptoms associated with Reye's syndrome relate to dysfunction of the liver and a resultant increase in serum ammonia levels and other toxins. These toxins cause increased pressure in the brain and swelling, leading to brain dysfunction and can progress to death.




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Reye's Syndrome

What are the basic functions of the liver?

The liver, located in the right upper portion of the abdominal cavity just beneath the right side of the rib cage, has many vital functions. Briefly, some of these functions are:

  • Detoxification of blood
  • Production of important clotting factor and other important proteins
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  • Production of glucose

What are common liver blood tests?

Liver blood tests are some of the most commonly performed blood tests. These tests can assess liver functions or liver injury. An initial step in detecting liver damage is a simple blood test to determine the presence of certain liver enzymes (proteins) in the blood. Under normal circumstances, these enzymes reside within the cells of the liv...

Read the Liver Blood Tests article »







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