ranitidine, Zantac

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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PRESCRIPTION: yes; OTC (Zantac 75 and 150 mg)

GENERIC AVAILABLE: yes

PREPARATIONS: Tablets or Capsules: 25, 75, 150 and 300 mg; Syrup: 15 mg/ml; Injection: 1 mg/ml or 25 mg/ml.

STORAGE: Tablets should be stored at room temperature between 15 C – 30 C (59 F - 86 F) in a tightly closed container. Syrup and injection should be stored between 4 C and 25 C (39 F and 77 F).

PRESCRIBED FOR: Ranitidine is useful in promoting the healing of ulcers in the stomach and duodenum, and in reducing ulcer pain. Ranitidine has been effective in preventing ulcer recurrence when given in low doses for prolonged periods of time. It also is used as needed for the treatment of occasional heartburn to  reflux of acid into the esophagus. In doses higher than that used for the treatment of ulcers, ranitidine has been helpful in treating heartburn and in healing ulcers and inflammation of the esophagus resulting from acid reflux (erosive esophagitis). It is also used for treating Zollinger Ellison syndrome, a syndrome caused by tumors that stimulate the stomach to produce large amounts of acid.

DOSING: Ranitidine may be taken with or without food.

  • Usual oral doses for treating ulcers and GERD are 150 mg twice daily or 300 mg at bedtime. The maintenance dose is 150 mg daily.
  • Erosive esophagitis is treated with 150 mg 4 times daily.
  • Zollinger Ellison syndrome may be treated with as much as 6 g daily.
  • Heartburn is treated with 75 mg or 150 mg once or twice daily 30-60 minutes before consuming meals or beverages that cause heartburn.

Self-medication should not last longer than 2 weeks unless advised by a physician.

DRUG INTERACTIONS: Ranitidine, like other drugs that reduce stomach acid, may interfere with the absorption of drugs that require acid for adequate absorption. Examples include iron salts (for example iron sulphate), itraconazole (Sporanox), and ketoconazole (Nizoral, Extina, Xolegel, Kuric).

Medically Reviewed by a Doctor on 9/14/2015

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