radium Ra 223 dichloride (Xofigo)

  • Medical Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

  • Pharmacy Author: Omudhome Ogbru, PharmD
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

GENERIC NAME: radium Ra 223 dichloride

BRAND NAME: Xofigo

DRUG CLASS AND MECHANISM: Radium Ra 223 (Xofigo) is a radioactive medicine (radiotherapeutic drug) that is used to treat male patients with symptoms of advanced prostate cancer that has spread to the bones, but not to other parts of the body. The radioactive particles emitted by radium Ra 223 helps kill cancer cells in the bone by damaging their DNA. Radium Ra 223 causes minimal damage to the nearby healthy cells. Radium Ra 223 can help some patients live longer. Compared to placebo, radium Ra 223 extended life by 14.9 months vs. 11.3 months for the placebo group. The FDA approved Radium Ra 223 in May 2013.

PRESCRIBED FOR: Radium Ra 223 is used for treating symptomatic metastatic castration-resistant prostate cancer that has spread to the bones but not to other parts of the body. Radium Ra 223 should only be used by male patients.

SIDE EFFECTS: The most common side effects of radium Ra 223 are:

To avoid dehydration caused by diarrhea, nausea, or vomiting, patients are advised to drink plenty of water and report any signs of dehydration such as dry mouth or increased thirst.

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