Rabies Virus (cont.)

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How do physicians diagnose rabies?

In animals, rabies is diagnosed by detecting the rabies virus in any affected part of the brain. This requires that the animal be euthanized. Testing a suspected animal will help avoid extensive testing in the human contact (if the test is negative) and unnecessary treatments.

In humans, rabies is diagnosed by testing saliva, blood samples, spinal fluid, and skin samples. Multiple tests may be necessary. The tests rely on detection of proteins on the surface of the rabies virus, detection of the genetic material of the virus, or demonstration of an antibody (immune) response to the virus.

What is the treatment for rabies?

Treatment is recommended if a health-care professional thinks that someone was exposed to a potentially rabid animal.

If the animal is a pet or farm animal that has no symptoms, the animal can be isolated and observed for 10 days. Wild animals that can be captured can be killed and tested for the virus. If the animal can't be found, it is best to consult with the local health department.

The general pathway to determine postexposure prophylaxis (protective treatment) for rabies requires the following information:

  • Bite: Did a bite occur, and where is the location of the bite? (Any penetration of the skin is considered a bite; although bites to the face and hands carry the highest risk, all bites need to be considered for prophylaxis.)
  • Non-bite incident: Did the saliva touch an open would or a mucous membrane?
  • Animal risk factors: No cases of rabies infection have been reported in the U.S. from fully vaccinated domestic dogs or cats.
  • Bats: Any contact with a bat that leads to a potential scratch, bite, or mucous membrane exposure to saliva needs to be evaluated. If prolonged exposure to a bat is discovered (sleeping in a room where a bat is found), postexposure prophylaxis needs to be considered.

As rabies is a fatal disease, it is often best to start the series of shots until further information is available.

A series of injections is given. The first is a rabies immune globulin that helps to prevent the virus from infecting the individual. Part of this immunization is given near the animal bite.

This is followed by four injections over the next two weeks. These are rabies vaccines to help the body fight the virus.

Medically Reviewed by a Doctor on 12/8/2014

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