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quinupristin/dalfopristin - injection, Synercid (cont.)

PRECAUTIONS: Before taking quinupristin/dalfopristin, tell your doctor or pharmacist if you are allergic to it; or to other streptogramin antibiotics (e.g., pristinamycin, virginiamycin); or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems, high levels of bilirubin in the blood (hyperbilirubinemia).During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: See also How to Use.Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.This drug can slow down the removal of certain medications from your body by affecting certain liver enzymes. These affected drugs include those that may affect the heart rhythm (QTc prolongation in the EKG), infrequently resulting in serious (rarely fatal) irregular heartbeat. Quinupristin/dalfopristin should not be used with the following medications because very serious interactions may occur: certain antiarrhythmic drugs (e.g., amiodarone, disopyramide, quinidine), cisapride, certain macrolide antibiotics (e.g., erythromycin, clarithromycin), certain antipsychotics (e.g., haloperidol, pimozide).If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting quinupristin/dalfopristin.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: digoxin.This drug can also slow down the removal of other drugs from your body by affecting certain liver enzymes. Before taking quinupristin/dalfopristin, tell your doctor or pharmacist if you are taking any of the following medications: certain drugs to suppress the immune system (e.g., cyclosporine, sirolimus, tacrolimus), certain drugs to treat HIV (e.g., delavirdine, indinavir, nevirapine, ritonavir), certain anti-cancer drugs (e.g., docetaxel, paclitaxel, vinblastine, vincristine), calcium channel blockers (e.g., diltiazem, nifedipine, verapamil), certain "statin" drugs to lower cholesterol (e.g., atorvastatin, lovastatin, simvastatin), certain benzodiazepines (e.g., diazepam, midazolam), carbamazepine, corticosteroids (e.g., methylprednisolone), drugs to treat erectile dysfunction (e.g., sildenafil, tadalafil, vardenafil).This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.



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