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quinupristin/dalfopristin - injection, Synercid (cont.)

HOW TO USE: This medication is given by injection into a vein by a health care professional, usually 2 to 3 times daily or as directed by your doctor. Quinupristin/dalfopristin must be properly prepared in a laminar air flow hood because the product does not contain preservatives. The medication must be mixed with the proper IV fluids (dextrose 5 percent in water solution). Before using this product, check it visually for particles or discoloration. If either is present, do not use the liquid. Infuse this medication slowly over 1 hour. If you have questions about the use of this medication, consult your pharmacist.If other medications are to be given through the same IV line, the IV line should be flushed before and after giving quinupristin/dalfopristin with a dextrose 5 percent in water solution. Do not flush the line with saline or heparin solutions because they are not compatible with this medication.The dosage is based on your medical condition, body weight, and response to treatment.Antibiotics work best when the amount of the medicine in your body is kept at a constant level. Therefore, use this drug at evenly spaced intervals (e.g., every 12 hours, every 8 hours).Continue to use this medication for the full time prescribed, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.Inform your doctor if your condition persists or worsens.

SIDE EFFECTS: Nausea, vomiting, diarrhea, and headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if you develop redness/swelling/pain/warming of the skin at the injection site. Flushing the IV line after each dose of this medication with dextrose 5 percent in water solution as directed will reduce the risk of vein irritation.Tell your doctor immediately if any of these unlikely but serious side effects occur: joint/muscle pain, yellowing eyes/skin, blood in the urine.Seek immediate medical attention if you experience this rare but very serious side effect: chest pain.This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor immediately if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.



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